Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated
Identifieur interne : 003E12 ( Main/Exploration ); précédent : 003E11; suivant : 003E13Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated
Auteurs : Noah Butler [États-Unis] ; Lecia Pewe [États-Unis] ; Kathryn Trandem [États-Unis] ; Stanley Perlman [États-Unis]Source :
- Virology [ 0042-6822 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Coronavirus humain OC43 (pathogénicité), Encéphalite virale (anatomopathologie), Encéphalite virale (mortalité), Encéphalite virale (médecine vétérinaire), Encéphalite virale (virologie), Humains, Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (physiopathologie), Infections à coronavirus (virologie), Lignée cellulaire, Moelle spinale (anatomopathologie), Souris, Souris de lignée C57BL, Spécificité d'espèce.
- MESH :
- anatomopathologie : Encéphalite virale, Moelle spinale.
- mortalité : Encéphalite virale.
- médecine vétérinaire : Encéphalite virale, Infections à coronavirus.
- pathogénicité : Coronavirus humain OC43.
- physiopathologie : Infections à coronavirus.
- virologie : Encéphalite virale, Infections à coronavirus.
- Animaux, Humains, Lignée cellulaire, Souris, Souris de lignée C57BL, Spécificité d'espèce.
English descriptors
- KwdEn :
- Animals, Cell Line, Coronavirus Infections (physiopathology), Coronavirus Infections (veterinary), Coronavirus Infections (virology), Coronavirus OC43, Human (pathogenicity), Encephalitis, Viral (mortality), Encephalitis, Viral (pathology), Encephalitis, Viral (veterinary), Encephalitis, Viral (virology), Humans, Mice, Mice, Inbred C57BL, Species Specificity, Spinal Cord (pathology).
- MESH :
- mortality : Encephalitis, Viral.
- pathogenicity : Coronavirus OC43, Human.
- pathology : Encephalitis, Viral, Spinal Cord.
- physiopathology : Coronavirus Infections.
- veterinary : Coronavirus Infections, Encephalitis, Viral.
- virology : Coronavirus Infections, Encephalitis, Viral.
- Animals, Cell Line, Humans, Mice, Mice, Inbred C57BL, Species Specificity.
Abstract
The human coronavirus HCoV-OC43 causes a significant fraction of upper respiratory tract infections. Most coronaviruses show a strong species specificity, although the SARS-Coronavirus crossed species from palm civet cats to infect humans. Similarly, HCoV-OC43, likely a member of the same coronavirus group as SARS-CoV, readily crossed the species barrier as evidenced by its rapid adaptation to the murine brain [McIntosh, K., Becker, W.B., Chanock, R.M., 1967. Growth in suckling-mouse brain of “IBV-like” viruses from patients with upper respiratory tract disease. Proc Natl Acad Sci U.S.A. 58, 2268–73]. Herein, we investigated two consequences of this plasticity in species tropism. First, we showed that HCoV-OC43 was able to infect cells from a large number of mammalian species. Second, we showed that virus that was passed exclusively in suckling mouse brains was highly virulent and caused a uniformly fatal encephalitis in adult mice. The surface glycoprotein is a major virulence factor in most coronavirus infections. We identified three changes in the HCoV-OC43 surface glycoprotein that correlated with enhanced neurovirulence in mice; these were located in the domain of the protein responsible for binding to host cells. These data suggest that some coronaviruses, including HCoV-OC43 and SARS-CoV, readily adapt to growth in cells from heterologous species. This adaptability has facilitated the isolation of HCoV-OC43 viral variants with markedly differing abilities to infect animals and tissue culture cells.
Url:
DOI: 10.1016/j.virol.2005.11.044
PubMed: 16413043
PubMed Central: 7111823
Affiliations:
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(virologie)</term><term>Humains</term><term>Infections à coronavirus (médecine vétérinaire)</term><term>Infections à coronavirus (physiopathologie)</term><term>Infections à coronavirus (virologie)</term><term>Lignée cellulaire</term><term>Moelle spinale (anatomopathologie)</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Spécificité d'espèce</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphalite virale</term><term>Moelle spinale</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Encephalitis, Viral</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Encéphalite virale</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Encéphalite virale</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Coronavirus OC43, Human</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus humain OC43</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Encephalitis, Viral</term><term>Spinal Cord</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term><term>Encephalitis, Viral</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Encéphalite virale</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Encephalitis, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Humans</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Species Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Lignée cellulaire</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Spécificité d'espèce</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The human coronavirus HCoV-OC43 causes a significant fraction of upper respiratory tract infections. Most coronaviruses show a strong species specificity, although the SARS-Coronavirus crossed species from palm civet cats to infect humans. Similarly, HCoV-OC43, likely a member of the same coronavirus group as SARS-CoV, readily crossed the species barrier as evidenced by its rapid adaptation to the murine brain [McIntosh, K., Becker, W.B., Chanock, R.M., 1967. Growth in suckling-mouse brain of “IBV-like” viruses from patients with upper respiratory tract disease. Proc Natl Acad Sci U.S.A. 58, 2268–73]. Herein, we investigated two consequences of this plasticity in species tropism. First, we showed that HCoV-OC43 was able to infect cells from a large number of mammalian species. Second, we showed that virus that was passed exclusively in suckling mouse brains was highly virulent and caused a uniformly fatal encephalitis in adult mice. The surface glycoprotein is a major virulence factor in most coronavirus infections. We identified three changes in the HCoV-OC43 surface glycoprotein that correlated with enhanced neurovirulence in mice; these were located in the domain of the protein responsible for binding to host cells. These data suggest that some coronaviruses, including HCoV-OC43 and SARS-CoV, readily adapt to growth in cells from heterologous species. This adaptability has facilitated the isolation of HCoV-OC43 viral variants with markedly differing abilities to infect animals and tissue culture cells.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Akashi, H" uniqKey="Akashi H">H. Akashi</name></author><author><name sortKey="Inaba, Y" uniqKey="Inaba Y">Y. Inaba</name></author><author><name sortKey="Miura, Y" uniqKey="Miura Y">Y. Miura</name></author><author><name sortKey="Sato, K" uniqKey="Sato K">K. Sato</name></author><author><name sortKey="Tokuhisa, S" uniqKey="Tokuhisa S">S. 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Storz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Iowa</li></region><settlement><li>Iowa City</li></settlement><orgName><li>Université de l'Iowa</li></orgName></list><tree><country name="États-Unis"><region name="Iowa"><name sortKey="Butler, Noah" sort="Butler, Noah" uniqKey="Butler N" first="Noah" last="Butler">Noah Butler</name></region><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><name sortKey="Pewe, Lecia" sort="Pewe, Lecia" uniqKey="Pewe L" first="Lecia" last="Pewe">Lecia Pewe</name><name sortKey="Trandem, Kathryn" sort="Trandem, Kathryn" uniqKey="Trandem K" first="Kathryn" last="Trandem">Kathryn Trandem</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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